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Single Best Answer: When Multiple Options Seem Correct

Sean P. Kane, PharmD, BCPS
By Sean P. Kane, PharmD, BCPS
Published June 27, 2025

Questions with Ranked Choices Are Preferred

Experts recommend a "single best answer" multiple-choice question format for assessing student knowledge, particularly in health sciences education. This format requires students to "rank" or "order" answer choices from least to most appropriate and ultimately select the best answer out of multiple plausible choices.

With this format, a common student complaint is that multiple answers seem equally correct. This problem typically arises when question writers attempt to create nuanced distinctions between good and better options, but fail to make these distinctions clear and defensible. Students who possess solid content knowledge may identify multiple plausible answers and struggle to determine which one the test creator intended as "best."

Critical Issue

When a question has multiple plausible answers, it introduces construct-irrelevant variance. The question no longer measures content knowledge alone, but also the student's ability to guess the instructor's intended answer. This undermines the validity of the assessment.

Consider the following example:

Quickest Transportation to an Appointment
You are running late for an important appointment and need to get there as quickly as possible. Which of the following is the most appropriate mode of transportation to choose?

A. Taking a taxi
B. Using a rideshare app ✓
C. Borrowing a bicycle via bikeshare app
D. Walking
Although answer B is selected as the most appropriate option, other answer choices could potentially be correct depending on the context (e.g., traffic conditions, distance, availability of rideshare drivers, etc.). The question does not provide adequate context for the test taker to intelligently select the best option.

Impact on Students

When students encounter questions with multiple defensible answers, they experience several negative effects:

  • Confusion and Frustration: Students who have mastered the content may become confused and frustrated when they cannot identify a single best answer.
  • Second-Guessing: The ambiguity can cause students to second-guess their knowledge and change correct answers to incorrect ones.
  • Loss of Confidence: Over time, exposure to poorly written questions can erode students' confidence in their own knowledge and in the fairness of the assessment process.

To avoid these issues, it is crucial to ensure that every question has a single, clear, and defensible best answer. This can be achieved through careful question writing, peer review, and post-exam analysis.

Examples of Single Best Answer Problems in Health Sciences Education

Flawed Question
A 70-year-old patient with stable chronic obstructive pulmonary disease (COPD) presents for a routine check-up. Which of the following is the most important intervention to recommend during this clinic visit?

A. Annual influenza vaccination
B. Smoking cessation counseling ✓
C. Long-term oxygen therapy
D. Prescribe a short-acting bronchodilator
All of these answer choices could potentially be correct depending on the context. "Most important" can be subjective without more context or a more specific question lead-in specifying the goal or reason for the intervention. If the patient has more severe COPD and flu season is approaching, answer A may be correct. If the patient is an active smoker and open to quitting, answer B may be reasonable. If the patient meets certain criteria for hypoxemia, answer C may be correct. If the patient is having worsening shortness of breath or wheezing, answer D may be reasonable.
Corrected Question
A 70-year-old patient with stable chronic obstructive pulmonary disease (COPD) who currently smokes 1 pack of cigarettes per day presents for a routine check-up. Which of the following interventions has the greatest potential to slow the progression of their COPD?

A. Annual influenza vaccination
B. Smoking cessation counseling and support ✓
C. Initiation of long-term oxygen therapy if PaO2 is < 55 mmHg
D. Prescription for a long-acting muscarinic antagonist (LAMA)
The corrected question specifies the patient is a current smoker and the goal of the intervention (slowing disease progression), making smoking cessation (B) the clear single best answer. The other options are relevant to COPD management but don't have the same impact on progression as quitting smoking. Option C adds a necessary condition for oxygen therapy. Option D is a standard maintenance therapy.

In this example, there is no nuance at all -- there are truly two equally correct answers, making the question flawed:

Flawed Question
Which of the following is a brand name for an HMG-CoA reductase inhibitor?

A. Lipitor
B. Lopressor
C. Norvasc
D. Zocor ✓
Both Lipitor (atorvastatin) and Zocor (simvastatin) are statin (HMG-CoA reductase inhibitor) medications. Norvasc (amlodipine) is a calcium channel blocker, and Lopressor (metoprolol) is a beta blocker. Since there are two correct answers, this question is flawed for a single best answer format.
Corrected Question
Which of the following is a brand name for an HMG-CoA reductase inhibitor?

A. Lasix
B. Lopressor
C. Norvasc
D. Zocor ✓
The corrected question asks for a single statin medication, making Zocor (simvastatin) the only correct answer. The other options are not statins.

Correcting Flaws with Single Best Answer Question Formats

When two answers are equally correct (as in the statin example above), the answer choices should be revised so that only a single answer choice is correct.

More commonly, however, is that a question is ambiguous or not specific enough to justify one answer being "more" correct over another. This problem can be addressed in several ways:

  1. Provide Specific Context: Include enough situational detail to make one option clearly superior. Specify patient characteristics, timing, clinical scenarios, or other relevant factors.

  2. Use Qualifying Language: Employ terms like "most appropriate," "priority," "immediate," or "essential" when there are clear hierarchies among options.

  3. Specify a Goal in the Question Stem: Instead of stating "which is most appropriate", provide a more specific question stem lead-in, such as "Which is most appropriate to reduce long-term mortality" or "Which is most appropriate to relieve the symptoms of dysuria".

Multiple defensible answers in exam questions frustrate students and compromise assessment validity. ExamEval provides AI-powered analysis that automatically detects ambiguous answer choices and recommends specific improvements to ensure each question has one defensible correct answer, helping health professions educators create more reliable and fair assessments.

References

  1. National Board of Medical Examiners (NBME). Item-Writing Guide. Philadelphia, PA: National Board of Medical Examiners; February 2021.
  2. Haladyna TM, Downing SM, Rodriguez MC. A review of multiple-choice item-writing guidelines for classroom assessment. Appl Meas Educ. 2002;15(3):309-334. doi:10.1207/S15324818AME1503_5

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